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The histologic differential diagnosis includes other spongiotic dermatoses such as atopic dermatitis, allergic contact dermatitis, id reaction, nummular dermatitis, seborrheic dermatitis, and dermatophytosis. Pityriasis Rosea (PR)-Like Drug Eruptions Often the histology is indistinguishable from typical PR reactions unrelated to drugs Histologic features are not specific, so biopsy is necessary. For the minor form of EM, healing usually takes about 2 to 4 weeks; the most severe major form (SJS) may last for a prolonged period of time and has a mortality rate of about 5%. 12,16 The increased mortality is due to a higher rate of bacterial superinfection and sepsis Histologic features of a skin biopsy sample obtained from a patient with lichen aureus shows extravasation of erythrocytes and a perivascular T-cell infiltrate. Endothelial cell swelling is a histologic feature of capillaritis Histological Features of Flagellate Erythema. In particular, subtle spongiosis and/or interface dermatitis combined with a dermal lymphocytic infiltrate that includes increased numbers of eosinophils is a common finding. Features of a lymphocytic vasculopathy may be seen in a subset of these cases The independent value of many histologic features of syphilis may be overestimated. Combinations of endothelial swelling, interstitial inflammation, irregular acanthosis, and elongated rete ridges should raise the possibility of syphilis, along with the presence of vacuolar interface dermatitis with
Histologically, claw-like epidermal extensions limit a localized area of lichenoid inflammation underlying the atrophic epidermis with parakeratosis. Ashy dermatosis also called erythema dyschromicum presents as widespread coalescing papules with epidermal atrophy, basal cell degeneration and pigmentary incontinence The histopathological features of the two groups present similar features that may help to identify an ongoing COVID-19 infection even in asymptomatic carriers with dermatosis. Significance We examined the histological features of 30 skin biopsies from two groups of patients: Ten specimens of patients tested positive for COVID-19 with an active. 1. Introduction. Dermatitis herpetiformis (DH) is an inflammatory cutaneous disease with typical histopathological and immunopathological findings clinically characterized by intensely pruritic polymorphic lesions with a chronic-relapsing course, first described by Duhring in 1884 .In 1966, Marks et al. . reported small-bowel changes in patients with DH and later gastrointestinal. The histological features of the two groups are summar-ized in Table 1. Clubbed and evenly elongated rete ridges were more common in the psoriasis group than in the se-borrheic dermatitis group (p＜0.05; Fig. 1A, B). Mounds of parakeratosis with neutrophils and spongiform micro-pustules of Kogoj were more frequently observed in th The histologic features of autoimmune progesterone dermatitis (APD) are generally non‐specific and have been described only in brief case reports. We present a case of APD and review the literature with a focus on the histologic findings described
dermatitis,33 nummular dermatitis, dyshidrotic dermatitis, seborrheic dermatitis, drug reactions, Id reaction, dermato-phytosis, miliaria,34 Gianotti-Crosti syndrome,35 and pityriasis rosea.36 Spongiotic dermatitis is further subclassified into acute, subacute, and chronic, depending on the histological features and the time the biopsy was. Background: Erosive pustular dermatosis of the scalp is a chronic eruption that leads to scarring alopecia A total of 19-38% of cases occur in pediatric patients, 94,95 commonly during the first decade of life, and the condition has been described at birth. 96 Some children show clinical and/or histological features of both acute and chronic form, suggesting considerable overlap and confirming the concept that these groups represent a spectrum of. Neutrophilic dermatosis of the dorsal hands (NDDH) presents as a localized variant of acute febrile neutrophilic dermatosis (i.e., Sweet syndrome) and was first described by Galaria et al 1 in 2000. Before this, a clinically similar phenomenon was characterized as pustular vasculitis of the hands in patients showing histological features of leukocytoclastic vasculitis. 2 It is likely.
The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histologic examination reveals intense epidermal, dermal, or hypodermal infiltrates composed primarily of neutrophils with no evidence of infection or true vasculitis [ 1 ] Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations Pigmented purpuric dermatitis affecting the trunk. Some of the lesions show the characteristic orange-brown, speckled, cayenne pepper-like discoloration that is the hallmark clinical sign of a capillaritis. Men are more frequently affected than women. If the lesions are pruritic, then the term itching purpura is sometimes used A hallmark histologic feature of dermatitis is edema between epidermal keratinocytes (spongiosis). When enough edema accumulates, cell-cell adhesions (desmosomes) rupture, forming microvesicles. The microvesicles become visible macroscopically only after they enlarge. In areas other than the hands and feet, these vesicles typically rupture. Because this histological syndrome shares some features with cutaneous lupus erythematosus or erythema multiforme, attempts to assign a specific name to the disease, in the absence of thymoma, have resulted in confusion, with authors describing similar cases as sebaceous adenitis, 7,8 lupus-like dermatitis, 9 drug reaction 2 or 'non-thymoma.
Histologic signs of papular dermatitis include spongiosis and superficial and deep perivascular mononuclear cell infiltrate with eosinophils . Most often, isolated eosinophilic spongiosis indicates the early stages of a subjacent autoimmune bullous dermatosis, such as the pemphigus group and.
Dermatosis. Dermatosis refers to diseases of the integumentary system. The histological diagnosis of cutaneous inflammatory diseases can be confusing as the immune system within the skin responds to antigenic stimuli in limited ways. Also, many inflammatory diseases do not show specific histological features. In view of this complexity and. Histologic analysis was available from 17 of the 20 patients. Nearly all cases (16 of 17 [94%]) showed features of lichenoid interface dermatitis (Figure 2A-C). In addition, many of the cases also showed features of spongiotic dermatitis (8 of 17 [47%]) Usually:A superficial perivascular inflammatory infiltrate. Often: Thinning of epidermal cells overlying the tips of dermal papillae (suprapapillary plates), and dilated, tortuous blood vessels within these papillae. Further histopathologic diagnosis is performed by the following parameters: Psoriasiform dermatitis
Histological Clues in Interpreting Vulvar Inflammatory and Autoimmune Dermatoses Regular (psoriasiform) acanthosis is a common feature of syphilis, and in these cases plasma cells are almost always seen in the inflammatory infiltrate. Many other infectious diseases including viral, bacterial, and fungal infections demonstrate irregular. The histological features in chronic superficial dermatitis are entirely non-specific. In fact, the constellation of histological findings is among the most often encountered by the dermatopathologist. Certainly, the vast majority of biopsies that show the changes described above do not represent chronic superficial dermatitis The histologic diagnosis of early mycosis fungoides (MF) and its distinction from inflammatory dermatoses is challenging, owing to the overlap of several features. 1) To assess the efficacy of. Inflammatory dermatoses are consistently one of the most challenging areas in dermatopathology for general surgical pathologists. There is significant overlap in histologic features that often. This article will describe the anatomy and histology of the skin.. Undoubtedly, the skin is the largest organ in the human body; literally covering you from head to toe. The organ constitutes almost 8-20% of body mass and has a surface area of approximately 1.6 to 1.8 m2, in an adult
Lichen aureus is the name given to localized pigmented purpuric dermatitis or capillaritis. In this patient, the skin on the extensor surface of the elbow is affected. Histologic features of a skin biopsy sample obtained from a patient with lichen aureus shows extravasation of erythrocytes and a perivascular T-cell infiltrate Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia. Background: Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermo-epidermal junction (DEJ). It is difficult to obtain a precise. The key features of facial discoid dermatosis are summarized in Table 2.While the clinical differential diagnosis included a number of entities, from psoriasis and cutaneous lupus erythematosus to contact dermatitis, the specific histologic features of these disorders were not only absent, but the findings among this group of patients were. INTRODUCTION. The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histologic examination reveals intense epidermal, dermal, or hypodermal infiltrates composed primarily of neutrophils with no evidence of infection or true vasculitis .Classification of the neutrophilic dermatoses is based upon the recognition of clinical and pathologic features, as. Important Features of Atopic Dermatitis 1. Early age at onset: • 70-90% by age 5 • 95% by age 15 2. Atopy • personal or family history • IgE reactivity 3. Xerosis . -Discribe histological features from the top down -The findings are not diagnostic for a specifi
clinical features. As both clinical and dermatopathological findings in mycosis fungoides occasionally closely imitate other dermatoses, correct diagnosis may be a challenge both for clinicians as well as dermatopathologists. As a consequence, diagnosis of cutaneous lymphoma may be initially missed and, therefore, prompt and adequat Histological features of 15 cases of psoriasis and 20 cases of seborrheic dermatitis Expression of Ki-67, keratin 10, and caspase-5 as the ratio of SA to measured E
Objectives: This review serves as an update on the clinical and histological features of canine AD published by the American College of Veterinary Dermatology Task Force on Canine Atopic Dermatitis in 2001 and summarizes the recent discoveries in these fields Common features found in the neutrophilic dermatoses. Histological features dominated by a neutrophilic vascular reaction, typically falling short of a vasculitis. A significant proportion have a reactive or underlying systemic association - mainly haematological, gastrointestinal, rheumatological or drug-induced. The conditions may coexist Although different types of dermatitis may differ in some minor histologic features, they cannot be clearly differentiated by histologic features alone. Eczema is synonymous with dermatitis but is often used, mainly by non-health care practitioners, to mean atopic dermatitis (a specific type of dermatitis)
Atopic dermatitis is a common, potentially debilitating condition that can compromise quality of life. Its most frequent symptom is pruritus. Attempts to relieve the itch by scratching simply. Eczema is a type of dermatitis characterized by prototypical gross and histological morphological features as well as particular clinical findings. A variety of etiologies can lead to eczematous rashes although in many cases no particular cause is found. The gross and histological morphology of eczema classically evolves between acute, subacute. . The characteristics of lichen striatus, blaschkitis, and BLAISE are reviewed. Case Presentation. Histological, immunohistochemical and ultrastructural study of 37 cases. J Cutan Pathol. 2001, 28:65-71 Histological diagnosis of allergic contact dermatitis is extremely difficult since the variability of morphologic patterns and the timing of biopsy. The histological findings that best describe this type of dermatitis are spongiosis that eventually leads to the formation of vesicles and bullae, and a mild perivascular inflammatory infiltrate. Especially CD8 + variants of mycosis fungoides tend to show distinct histological features. These include a subtle to prominent interface dermatitis with vacuolar degeneration of keratinocytes, subepidermal blistering/papillary edema in the absence of antiepidermal antibodies, or purpuric changes
In many cases, GA showed interstitial-type histology, arising challenges in differential diagnosis with IGD. The overlap of clinical and histological features of GA and IGD can be explained considering them as a broad disease spectrum, including also the other forms of reactive granulomatous dermatitis Of 200 atopic dermatitis patients observed during cold months, 44 (22%) had ichthyosis vulgaris. Histologically, the dry skin in atopic dermatitis coexistent with ichthyosis demonstrated ichthyotic features which were frequently superimposed with eczematous changes. The dry skin in pure atopic dermatitis demonstrated the histology of mild eczema The gene expression findings were corroborated by tissue sample histology which demonstrated features of Th17-driven psoriasiform dermatitis in combination with the classical Th2-driven spongiosis. The histology of transient acantholytic dermatosis (Grover disease) contains certain characteristic features, but for a precise diagnosis to be rendered, clinicopathologic correlation is needed (see the images below). Typically, focal acantholysis and dyskeratosis are seen
Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. SPD is similar to two other disease entities. Both SPD-type immunoglobulin (Ig)-A pemphigus and. Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale (Wickham's striae), commonly affecting dorsal hands, flexural. Subcorneal pustular dermatosis (SCPD, also known as Sneddon-Wilkinson disease) is a rare, benign, chronic, sterile pustular eruption which usually develops in middle-age or elderly women; it is rarely seen in childhood and adolescence. The primary lesions are pea-sized pustules classically described as half-pustular, half-clear flaccid blisters. Histologically the most important feature is a.
features that have traditionally been included as Interface dermatitis. All these inflammatory skin diseases are associated with a set of histological features, primarily involving the dermo-epidermal junction. Sustained interface reactions often result in loss of pigment from basal cells and their ingestion by melanophages. The lesion Background: Neutrophilic dermatoses are a collection of diseases with varying presentation unified by clinical and histologic features. Neutrophilic dermatosis of the dorsal hands is a recently described clinical entity and an evolving disease concept A broad analysis of histological lesions delineate the history of the neutrophilic dermatoses. In all steps of the description of these diseases, the cutaneous biopsy has been essential to ascertain their specificity. Moreover, some of them have been distinguished in accordance with their histological presentation The key features of facial discoid dermatosis are summarized in Table 2 . 2 Key features of facial discoid dermatosis Facial discoid dermatosis Discoid Minimal dry scale, may be annular Limited to the face Stable over years Treatment‐resistant Nonspecific histology, with features resembling pityriasis rubra pilaris While the clinical. Histologic features of autosensitization dermatitis include parakeratosis admixed with serum in the stratum corneum, intraepidermal spongiosis with occasional microvesiculation, and a lymphohistiocytic infiltrate surrounding vessels within the superficial vascular plexus (Figs. 1.17, 1.18 and 1.19). Eosinophils are generally not abundant, in.
How is interstitial granulomatous dermatitis diagnosed? Interstitial granulomatous dermatitis is diagnosed by a pathologist on examining a skin biopsy. The characteristic histological features of interstitial granulomatous dermatitis are: Dense histiocytic inflammation in the reticular (lower) dermis Sparse neutrophils and eosinophil The hallmark feature of epidermal basal layer injury was the most correlated finding in our study as well as those of Kumar et al. and Chauhan et al. Civatte bodies, though one of the key histologic features of lichenoid IFD, were found to be less correlated in ours (41.93%) and other similar studies Allergic and irritant contact dermatitis 1. INTRODUCTION • CD defined as an inflammatory process affecting skin • Induced by contact with chemical, physical and/or biotic agents in environment, • Causes lesions of skin, mucosa and semi-mucosa by means of allergic and irritant pathogenic mechanisms Papular dermatitis (PD) is a subacute or chronic pruritic skin disease of unknown etiology, often refractory to con- PD is the accepted term to describe such patients with similar clinical and histopathologic features. Signs and symptoms include pruritic skin-colored or erythema- tion. Histology shows prominent perivascular and. Granulomatous pigmented purpuric dermatosis (GPPD) is a rare entity with few cases reported in the literature. We report 3 cases of pigmented purpuric dermatosis (PPD) with granulomatous features in a 9-year-old boy, a 49-year-old woman, and a 75-year-old woman. We also review the literature on PPDs with granulomatous features, including histopathologic features and disease associations
Broadly, granulomatous dermatitis is divided into two groups—infectious and non-infectious, the prevalence of both highly variable and show overlapping pathology. However, there are subtle histological clues, which when combined with clinical features, help to narrow down the differential diagnosis IGD has a variable clinical presentation and highly characteristic histological features of interstitial infiltrate of histiocytes between the degenerated collagen bundles. Here we report the case of a 63-year-old woman who presented with a 3-month history of multiple asymptomatic erythematous papules on the bilateral aspects of the trunk Classic and non-classic histologic features of psoriasis were evaluated in this study of 51 biopsies from 46 patients with clinically confirmed psoriasis. Classic histologic features were present in the majority of cases and included club-shaped rete ridges (96%), hypogranulosis (96%), Munro microabscess (78%), and spongiform pustule of Kogoj. The main features of pigmented purpuric dermatosis (PPD) are petechiae (tiny red spots due to broken blood vessels) or purpura (purple-colored spots or patches due to broken blood vessels), and yellow to brown pigmented patches. The most common sites are the legs, although lesions also may develop in other areas Although different types of dermatitis may differ in some minor histologic features, they cannot be clearly differentiated by histologic features alone. Eczema is synonymous with dermatitis but is often used, mainly by non-health care practitioners, to mean atopic dermatitis (a specific type of dermatitis). Lichenoid dermatitis and interphase.
Dr. Soeprono teaches and practices dermatopathology at Loma Linda University, School of Medicine, Department of Dermatology. He also practices dermatology at the Advanced Dermatology & Laser Center of Redlands, CA and dermatopathology privately. histopathology library. View information about other entities available on this website LP-like lichenoid/interface dermatitis- the prototype of a lichenoid dermatitis with prominent basal epidermal keratinocyte death colloid bodies (point out). Note the band-like infiltrate of lymphocytes in the dermis—this is a histologic feature which also defines lichenoid in the minds of most dermatopathologists However, certain histologic features may point toward a particular entity such as the following: • Keratin changes . Parakeratosis, particularly when also containing the nuclear remnants of neutrophils, should suggest psoriasis, seborrheic dermatitis, or a fungal infection
histological criterion of preliminary mycosis fungoides may be achieved with an appropriate clinical and pathologic concordance  (Figures 1-6). Numerous histological configurations of inflammatory dermatosis may simulate the preliminary lesions, thus an accurate categorization on histopathology may be challenging
Contact dermatitis is the most common professional skin disease, with frequencies ranging from 24 to 170 every 100000 people.Approximately 20% of the United States population suffers from CD, causing loss of over four million work days and costing approximately $400 million per year[3-5].CD is classified into irritant (ICD) and allergic (ACD), with both subtypes displaying sub-acute, acute. Stasis dermatitis, also called gravitational dermatitis, venous eczema, and venous stasis dermatitis, happens when there is venous insufficiency, or poor circulation in the lower legs. Venous insufficiency happens when the valves in leg veins that help push blood back to the heart weaken and leak fluid. This allows water and blood cells to pool. Acute eczematous dermatitis. Eczema means to boil over. All forms of eczema characterized by: Red, papulovesicular, oozing, and crusted lesions that develop into raised, scaling plaques due to reactive acanthosis and hyperkeratosis. 5 categories of acute eczematous dermatitis. (1) allergic contact dermatitis The hallmark histological feature of any eczematous lesion, including atopic dermatitis, is spongiosis. Spongiosis refers to edema and thus increased space between keratinocytes of the spiny layer of the epidermis. The desmosomes between keratinocytes are typically preserved and thus the keratinocytes appear to be separated by a spongy layer histology •Subepidermal blister •Often features of erosions or ulcers lined by granulation tissue showing non-specific acute or chronic inflammation •Variable infiltrate of cells in its base -neutrophilic microabcesses in dermal papillae (DH-like) (acute lesions, <48 hours) -increasing numbers of lymphocytes an
Clinical features and anamnesis were similar to those. Histology of Canine Dermatoses 5S1 described in the literature [5, 6]. Greasy or scaly partially alopecic dermal lesions with out acco mpanying pruritus were typical. Histologically, there was aca nthosis in 79 of 80 dogs (99%) (table I; fig. l). Th The authors demonstrated that the histology of NEAE can be classified into 3 patterns that of eosinophilic granulomatous panniculitis (7/12 cases), eosinophilic dermatitis without granuloma formation (3/12 cases), and invisible dermatosis (2/12 cases) A NOTE ON THE HISTOLOGY OF DERMATITIS EXFOLIATIVA NEONATORUM A NOTE ON THE HISTOLOGY OF DERMATITIS EXFOLIATIVA NEONATORUM SKINNER, E. F. 1910-03-01 00:00:00 A NOTE ON THE HISâ Iâ OLOGY OF DERMAlâ Iâ lâ IS EXFOLIATIVA NEONATORUM. BY E. F. SKINNER, M.A., M.B.CANTAB.,M.R.C.P., Clinical Assistant to the Department for Diseases of the Ski%, Shefield Royal Hospital; Medical Oficer in Charge of. Recommended initial management by obstetrician: Order complete blood count (CBC), liver function tests (LFTs), thyroid function tests (TFTs), and bile acids to rule out other dermatoses of pregnancy. 2 If necessary, perform two 3-0 punch biopsies, one from a papule or plaque for hematoxylin and eosin (H&E) staining and the other on perilesional uninvolved skin for direct immunofluorescence. Clinical features and histological findings of urticarial dermatitis (UD) and adult-onset atopic dermatitis (AD). (A) Clinical features show urticarial erythematous papules, plaques, and patches on the right flank of a patient with UD. (B) Clinical features of a patient with adult-onset AD show erythematous excoriated papules on the abdomen
The clinical presentation, histological features, and excellent response to corticosteroid treatment are consistent with diagnosis of NDDH. Delayed recognition of neutrophilic dermatosis and treatment of secondary infection resulted in delayed treatment. Improved recognition of neutrophilic dermatoses is important for optimal management of NDDH BACKGROUND Neutrophilic dermatoses are a collection of diseases with varying presentation unified by clinical and histologic features. Neutrophilic dermatosis of the dorsal hands is a recently described clinical entity and an evolving disease concept. Its relationship to acute febrile neutrophilic dermatosis (Sweet syndrome), pyoderma. Bullous dermatoses are a heterogeneous group of skin diseases manifested by different clinical pictures, occasion-ally with overlapping features, but always with the occurrence of bullae as their major characteristic.1-14 The classification of bullous diseases is based on three morpho-logic characteristics
A and B, Perivascular lymphohistiocytic inflammation without the classic histologic features of dermatitis herpetiformis. Fibrillar IgA ( C ) and IgG ( D ) deposition present in the companion biopsy submitted for direct immunofluorescent (DIF) staining Histological features of 15 cases of psoriasis and 20 cases of seborrheic dermatitis Click for larger image Click for full table Download as Excel file Significantly increased numbers of mitotic figures were observed in the psoriasis group compared to the seborrheic dermatitis group (mean±standard deviation [SD], 5.1±2.1 vs. 4.3±1.5; p <0.05) CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Summary Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis All cases showing interface dermatitis as a major histological finding were included. A total of 71 cases were studied. All sections were examined in detail and the associated histological features of each category of interface dermatitis were noted. Specific histological features aiding in differentiation of each category was assessed Classic histologic features of dermatitis herpetiformis include collections of neutrophils at the dermal papillae and subepidermal blisters with neutrophils (H&E, ×400). Image 1. Open in new tab Download slide